YY1

YY1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1UBD, 1ZNM, 4C5I
معین‌کننده‌ها
نام‌های دیگر	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
شناسه‌های بیرونی	OMIM: 600013 MGI: 99150 HomoloGene: 2556 GeneCards: YY1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۲ (موش)
پایان	108,786,074 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001105 transcription coactivator activity; • zinc ion binding; • metal ion binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • four-way junction DNA binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • RNA binding; • nucleic acid binding; • SMAD binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078، GO:0001214، GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • sequence-specific DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding;
ترکیبات سلولی	• Ino80 complex; • ماتریکس هسته ای; • هسته یاخته; • نوکلئوپلاسم; • transcription regulator complex; • سیتوپلاسم; • PcG protein complex;
فرایند زیستی	• دگرگونی یاخته‌; • DNA recombination; • GO:0009373 regulation of transcription, DNA-templated; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • cellular response to UV; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • double-strand break repair via homologous recombination; • اسپرماتوژنز; • GO:0100026 بازسازی دی‌ان‌ای; • protein deubiquitination; • negative regulation of interferon-beta production; • GO:1901227 negative regulation of transcription by RNA polymerase II; • RNA localization; • anterior/posterior pattern specification; • response to UV-C; • GO:1901313 positive regulation of gene expression; • response to prostaglandin F; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • camera-type eye morphogenesis; • GO:0051312، GO:0007083 chromosome organization; • cellular response to interleukin-1; • negative regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of cell growth involved in cardiac muscle cell development;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7528
	22632
	ENSG00000100811
	ENSMUSG00000021264
	P25490
	Q00899
	NM_003403
	XM_036157387، XR_004937493 NM_009537، XM_036157387، XR_004937493
	NP_003394
	XP_036013280 NP_033563، XP_036013280
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

یین یانگ ۱ (انگلیسی: Yin Yang 1)^[۴] یک پروتئین سرکوب‌کنندهٔ رونویسی است که در انسان توسط ژن «YY1» کُدگذاری می‌شود.^[۵]^[۶] نام این پروتئین از مفهوم کهن یین و یانگ گرفته شده‌است.

اهمیت بالینی

در صورت جهش حذفی، جهش بدمعنی و جهش بی‌معنی در ژن «YY1»، «سندرم گابریله-دو وِریش» (GADEVS) رخ می‌دهد^[۷]^[۸] که یک نقص تکاملی عصبی است که مبتلایانش دچار ناتوانی‌های هوشی، ناهنجاری‌های چهره، مشکلات تغذیه‌ای، عقب‌ماندگی رشد داخل رحمی، ناتوانی‌های شناختی، اختلالات رفتاری و تعدادی دیگر از ناهنجاری‌های مادرزادی هستند.^[۹] این بیماری نامش را از دانشمند ایتالیایی «میکله گابریله» و دانشمند هلندی «پترا دو وِریش» می‌گیرد که نخستین بار آنرا شرح دادند. وبگاهی مختص این بیماری موجود است که به جمع‌آوری اطلاعات دربارهٔ آن می‌پردازد و آنرا در اختیار پزشکان و خانواده‌های درگیر با این بیماری قرار می‌دهد.^[۱۰]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021264 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
↑ Shi Y, Seto E, Chang LS, Shenk T (Oct 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
↑ Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122.
↑ "OMIM:GABRIELE-DE VRIES SYNDROME".
↑ Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E.; Bean LJH; Stephens, K.; Amemiya, A. (1993). "Gabriele-de Vries Syndrome". PMID 31145572. {{cite journal}}: Cite journal requires |journal= (help)
↑ Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.
↑ "YY1 - Collect information about clinic management and research projects". YY1.

مشارکت‌کنندگان ویکی‌پدیا. «YY1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Thomas MJ, Seto E (Aug 1999). "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene. 236 (2): 197–208. doi:10.1016/S0378-1119(99)00261-9. PMID 10452940.
Park K, Atchison ML (Nov 1991). "Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9804–8. doi:10.1073/pnas.88.21.9804. PMC 52809. PMID 1946405.
Yang WM, Inouye CJ, Seto E (Jun 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The Journal of Biological Chemistry. 270 (25): 15187–93. doi:10.1074/jbc.270.25.15187. PMID 7541038.
Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
Zhou Q, Gedrich RW, Engel DA (Jul 1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". Journal of Virology. 69 (7): 4323–30. PMC 189172. PMID 7769693.
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081.
Becker KG, Swergold GD, Ozato K, Thayer RE (Oct 1993). "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Human Molecular Genetics. 2 (10): 1697–702. doi:10.1093/hmg/2.10.1697. PMID 8268924.
Margolis DM, Somasundaran M, Green MR (Feb 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–10. PMC 236527. PMID 8289393.
Lee JS, Galvin KM, Shi Y (Jul 1993). "Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1". Proceedings of the National Academy of Sciences of the United States of America. 90 (13): 6145–9. doi:10.1073/pnas.90.13.6145. PMC 46884. PMID 8327494.
Yang WM, Inouye C, Zeng Y, Bearss D, Seto E (Nov 1996). "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12845–50. doi:10.1073/pnas.93.23.12845. PMC 24008. PMID 8917507.
Houbaviy HB, Usheva A, Shenk T, Burley SK (Nov 1996). "Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator". Proceedings of the National Academy of Sciences of the United States of America. 93 (24): 13577–82. doi:10.1073/pnas.93.24.13577. PMC 19349. PMID 8942976.
Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Feb 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
Cole EG, Gaston K (Sep 1997). "A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors". Nucleic Acids Research. 25 (18): 3705–11. doi:10.1093/nar/25.18.3705. PMC 146936. PMID 9278494.
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (Oct 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
Romerio F, Gabriel MN, Margolis DM (Dec 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–82. PMC 230241. PMID 9371597.
McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS (Mar 1998). "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". Journal of Cellular Biochemistry. 68 (4): 500–10. doi:10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U. PMID 9493912.
Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM (Jun 1998). "Design, synthesis and structure of a zinc finger with an artificial beta-turn". Journal of Molecular Biology. 279 (4): 973–86. doi:10.1006/jmbi.1998.1764. PMID 9642075.
Yao YL, Dupont BR, Ghosh S, Fang Y, Leach RJ, Seto E (Aug 1998). "Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1". Nucleic Acids Research. 26 (16): 3776–83. doi:10.1093/nar/26.16.3776. PMC 147783. PMID 9685495.

پیوند به بیرون

YY1 در دانشنامهٔ اجزای دی‌ان‌ای

خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: P25490 (Transcriptional repressor protein YY1) در PDBe-KB.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021264 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.

[pmid_1655281-5] Shi Y, Seto E, Chang LS, Shenk T (Oct 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.

[pmid_7912122-6] Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122.

[7] "OMIM:GABRIELE-DE VRIES SYNDROME".

[8] Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E.; Bean LJH; Stephens, K.; Amemiya, A. (1993). "Gabriele-de Vries Syndrome". PMID 31145572. {{cite journal}}: Cite journal requires |journal= (help)

[YY1_Haploinsufficiency_Causes_an_Intellectual_Disability_Syndrome_Featuring_Transcriptional_and_Chromatin_Dysfunction.-9] Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.

[10] "YY1 - Collect information about clinic management and research projects". YY1.

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