فاکتور ۲۳ رشد فیبروبلاست

FGF23
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2P39
معین‌کننده‌ها
نام‌های دیگر	FGF23, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
شناسه‌های بیرونی	OMIM: 605380 MGI: 1891427 HomoloGene: 10771 GeneCards: FGF23
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	127,058,371 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• fibroblast growth factor receptor binding; • type 1 fibroblast growth factor receptor binding; • growth factor activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 1-phosphatidylinositol-3-kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• extracellular region; • Golgi lumen; • endoplasmic reticulum lumen; • extracellular space;
فرایند زیستی	• دگرگونی یاخته‌; • negative regulation of bone mineralization; • cellular response to interleukin-6; • vitamin D metabolic process; • regulation of bone mineralization; • phosphate ion homeostasis; • cellular phosphate ion homeostasis; • response to magnesium ion; • regulation of phosphate transport; • cellular response to vitamin D; • negative regulation of osteoblast differentiation; • cellular response to leptin stimulus; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • fibroblast growth factor receptor signaling pathway; • response to sodium phosphate; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of vitamin D 24-hydroxylase activity; • phosphate-containing compound metabolic process; • vitamin D catabolic process; • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; • cellular response to parathyroid hormone stimulus; • negative regulation of hormone secretion; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • phosphatidylinositol-3-phosphate biosynthetic process; • MAPK cascade; • پیرایش پسارونویسی; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8074
	64654
	ENSG00000118972
	ENSMUSG00000000182
	Q9GZV9
	Q9EPC2
	NM_020638
	XM_036152259 NM_022657، XM_036152259
	NP_065689
	XP_036008152 NP_073148، XP_036008152
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور ۲۳ رشد فیبروبلاست (انگلیسی: Fibroblast growth factor 23) با نام اختصاری FGF-23 یک پروتئین و عضوی از خانواده فاکتور رشد فیبروبلاست (FGF) است که در تنظیم فسفات در پلاسما و متابولیسم ویتامین دی شرکت می‌کند^[۴]^[۵] و در انسان توسط ژن «FGF23» بر روی بازوی بلند کروموزوم ۱۲ کدگذاری می‌شود.^[۶] FGF-23 باعث کاهش بازجذب فسفات در کلیه و افزایش دفع ادراری آن می‌شود. جهش در FGF23 می‌تواند منجر به افزایش فعالیت آن و بروز «راشیتیسم اتوزومال غالب با فسفات کم» شود.^[۷]

این فاکتور توسط استئوسیت و در پاسخ به افزایش کلسیتریول و فسفات ترشح می‌شود و اثر خود را بر روی لوله پیچیده نزدیک^[۸]^[۹]^[۱۰]^[۱۱] در کلیه اِعمال می‌کند.^[۱۲] FGF-23 با سرکوب ۱-آلفا-هیدروکسیلاز و کاهش عملکرد آن در زمینه فعال‌سازی ویتامین دی سبب اختلال در جذب کلسیم می‌گردد.^[۵]^[۱۳]

مشاهده گردیده است که در برخی انواع تومورها همچون تومور مزانشیمی خوش‌خیم فوسفاتوریک، تولید و ترشح FGF-23 زیاد می‌شود و منجر به نرم‌استخوانی ناشی از تومور می‌گردد که نوعی سندرم پارانئوپلاستیک است.^[۱۴]^[۱۵]

تولید بیش از حد FGF-23 با افزایش بیماری قلبی عروقی در بیماران دچار نارسایی مزمن کلیه (از جمله هیپرتروفی قلب، کلسیفیکاسیون عروق، سکته مغزی و اختلال عملکرد لایهٔ درون‌رگی) مرتبط است.^[۱۶]

کمبود آهن و التهاب هردو می‌توانند بر تولید یا تجزیهٔ مولکول FGF-23 اثر بگذارند.^[۱۷]

در مطالعات آزمایشگاهی بر روی موش‌ها مشاهده شده که فقدان فاکتور ۲۳ رشد فیبروبلاست یا کلوتو سبب پیری زودرس ناشی از فسفات زیاد در خون می‌شود.^[۱۸]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000000182 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fukumoto S (2008). "Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23". Internal Medicine. 47 (5): 337–343. doi:10.2169/internalmedicine.47.0730. PMID 18310961.
↑ ^۵٫۰ ^۵٫۱ Perwad F, Zhang MY, Tenenhouse HS, Portale AA (November 2007). "Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro". American Journal of Physiology. Renal Physiology. 293 (5): F1577–F1583. doi:10.1152/ajprenal.00463.2006. PMID 17699549. S2CID 20559055.
↑ Yamashita T, Yoshioka M, Itoh N (October 2000). "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain". Biochemical and Biophysical Research Communications. 277 (2): 494–498. doi:10.1006/bbrc.2000.3696. PMID 11032749.
↑ "Entrez Gene: FGF23 fibroblast growth factor 23".
↑ Dance A (23 February 2022). "Fun facts about bones: More than just scaffolding". Knowable Magazine. doi:10.1146/knowable-022222-1. S2CID 247095495. Retrieved 8 March 2022.
↑ Robling AG, Bonewald LF (February 2020). "The Osteocyte: New Insights". Annual Review of Physiology. 82 (1): 485–506. doi:10.1146/annurev-physiol-021119-034332. PMC 8274561. PMID 32040934.
↑ Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, Huang CL (July 2008). "Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1". Proceedings of the National Academy of Sciences of the United States of America. 105 (28): 9805–9810. Bibcode:2008PNAS..105.9805C. doi:10.1073/pnas.0803223105. PMC 2474477. PMID 18606998.
↑ Brown RB, Razzaque MS (January 2018). "Chapter 31 - Endocrine Regulation of Phosphate Homeostasis". In Singh AK, Williams GH (eds.). Textbook of Nephro-Endocrinology (به انگلیسی) (Second ed.). Academic Press. pp. 539–548. doi:10.1016/b978-0-12-803247-3.00032-5. hdl:10012/15679. ISBN 978-0-12-803247-3. S2CID 102827267.
↑ Jüppner H (April 2011). "Phosphate and FGF-23". Kidney International. Supplement. 79 (121): S24–S27. doi:10.1038/ki.2011.27. PMC 3257051. PMID 21346724.
↑ Rodríguez-Ortiz ME, Rodríguez M (2015). "FGF23 as a calciotropic hormone". F1000Research. 4: 1472. doi:10.12688/f1000research.7189.1. PMC 4815615. PMID 27081473.
↑ Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?". Oral Oncology. 48 (2): e9-10. doi:10.1016/j.oraloncology.2011.09.011. PMID 21985764.
↑ Green D, Mohorianu I, Piec I, Turner J, Beadsmoore C, Toms A, Ball R, Nolan J, McNamara I, Dalmay T, Fraser WD (December 2017). "MicroRNA expression in a phosphaturic mesenchymal tumour". Bone Reports. 7: 63–69. doi:10.1016/j.bonr.2017.09.001. PMC 5596358. PMID 28932769.
↑ Beck-Nielsen SS, Mughal Z, Haffner D, Nilsson O, Levtchenko E, Ariceta G, de Lucas Collantes C, Schnabel D, Jandhyala R, Mäkitie O (February 2019). "FGF23 and its role in X-linked hypophosphatemia-related morbidity". Orphanet Journal of Rare Diseases. 14 (1): 58. doi:10.1186/s13023-019-1014-8. PMC 6390548. PMID 30808384.
↑ David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, Zumbrennen-Bullough KB, Sun CC, Lin HY, Babitt JL, Wolf M (January 2016). "Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production". Kidney International. 89 (1): 135–146. doi:10.1038/ki.2015.290. PMC 4854810. PMID 26535997.
↑ Huang CL (May 2010). "Regulation of ion channels by secreted Klotho: mechanisms and implications". Kidney International. 77 (10): 855–860. doi:10.1038/ki.2010.73. PMID 20375979.

برای مطالعهٔ بیشتر

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Silve C, Beck L (June 2002). "Is FGF23 the long sought after phosphaturic factor phosphatonin?". Nephrology, Dialysis, Transplantation. 17 (6): 958–961. doi:10.1093/ndt/17.6.958. PMID 12032180.
Quarles LD (July 2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization". American Journal of Physiology. Endocrinology and Metabolism. 285 (1): E1–E9. doi:10.1152/ajpendo.00016.2003. PMID 12791601.
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Campos M, Couture C, Hirata IY, Juliano MA, Loisel TP, Crine P, Juliano L, Boileau G, Carmona AK (July 2003). "Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein". The Biochemical Journal. 373 (Pt 1): 271–279. doi:10.1042/BJ20030287. PMC 1223479. PMID 12678920.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000000182 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18310961-4] Fukumoto S (2008). "Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23". Internal Medicine. 47 (5): 337–343. doi:10.2169/internalmedicine.47.0730. PMID 18310961.

[pmid17699549-5] ۵٫۰ ^۵٫۱ Perwad F, Zhang MY, Tenenhouse HS, Portale AA (November 2007). "Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro". American Journal of Physiology. Renal Physiology. 293 (5): F1577–F1583. doi:10.1152/ajprenal.00463.2006. PMID 17699549. S2CID 20559055.

[pmid11032749-6] Yamashita T, Yoshioka M, Itoh N (October 2000). "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain". Biochemical and Biophysical Research Communications. 277 (2): 494–498. doi:10.1006/bbrc.2000.3696. PMID 11032749.

[entrez-7] "Entrez Gene: FGF23 fibroblast growth factor 23".

[Dance-8] Dance A (23 February 2022). "Fun facts about bones: More than just scaffolding". Knowable Magazine. doi:10.1146/knowable-022222-1. S2CID 247095495. Retrieved 8 March 2022.

[Robling-9] Robling AG, Bonewald LF (February 2020). "The Osteocyte: New Insights". Annual Review of Physiology. 82 (1): 485–506. doi:10.1146/annurev-physiol-021119-034332. PMC 8274561. PMID 32040934.

[pmid18606998-10] Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, Huang CL (July 2008). "Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1". Proceedings of the National Academy of Sciences of the United States of America. 105 (28): 9805–9810. Bibcode:2008PNAS..105.9805C. doi:10.1073/pnas.0803223105. PMC 2474477. PMID 18606998.

[11] Brown RB, Razzaque MS (January 2018). "Chapter 31 - Endocrine Regulation of Phosphate Homeostasis". In Singh AK, Williams GH (eds.). Textbook of Nephro-Endocrinology (به انگلیسی) (Second ed.). Academic Press. pp. 539–548. doi:10.1016/b978-0-12-803247-3.00032-5. hdl:10012/15679. ISBN 978-0-12-803247-3. S2CID 102827267.

[pmid21346724-12] Jüppner H (April 2011). "Phosphate and FGF-23". Kidney International. Supplement. 79 (121): S24–S27. doi:10.1038/ki.2011.27. PMC 3257051. PMID 21346724.

[pmid27081473-13] Rodríguez-Ortiz ME, Rodríguez M (2015). "FGF23 as a calciotropic hormone". F1000Research. 4: 1472. doi:10.12688/f1000research.7189.1. PMC 4815615. PMID 27081473.

[TIO-14] Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?". Oral Oncology. 48 (2): e9-10. doi:10.1016/j.oraloncology.2011.09.011. PMID 21985764.

[pmid28932769-15] Green D, Mohorianu I, Piec I, Turner J, Beadsmoore C, Toms A, Ball R, Nolan J, McNamara I, Dalmay T, Fraser WD (December 2017). "MicroRNA expression in a phosphaturic mesenchymal tumour". Bone Reports. 7: 63–69. doi:10.1016/j.bonr.2017.09.001. PMC 5596358. PMID 28932769.

[Beck-Nielsen-16] Beck-Nielsen SS, Mughal Z, Haffner D, Nilsson O, Levtchenko E, Ariceta G, de Lucas Collantes C, Schnabel D, Jandhyala R, Mäkitie O (February 2019). "FGF23 and its role in X-linked hypophosphatemia-related morbidity". Orphanet Journal of Rare Diseases. 14 (1): 58. doi:10.1186/s13023-019-1014-8. PMC 6390548. PMID 30808384.

[David-17] David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, Zumbrennen-Bullough KB, Sun CC, Lin HY, Babitt JL, Wolf M (January 2016). "Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production". Kidney International. 89 (1): 135–146. doi:10.1038/ki.2015.290. PMC 4854810. PMID 26535997.

[pmid20375979-18] Huang CL (May 2010). "Regulation of ion channels by secreted Klotho: mechanisms and implications". Kidney International. 77 (10): 855–860. doi:10.1038/ki.2010.73. PMID 20375979.

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