پرش به محتوا

CD82

از ویکی‌پدیا، دانشنامهٔ آزاد
CD82
معین‌کننده‌ها
نام‌های دیگرCD82, 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
شناسه‌های بیرونیOMIM: 600623 MGI: 104651 HomoloGene: 20512 GeneCards: CD82
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

3732

12521

آنسامبل

ENSG00000085117

ENSMUSG00000027215

یونی‌پروت

P27701

P40237

RefSeq (mRNA)

NM_001024844، NM_002231، XM_006718223 XM_011520067، NM_001024844، NM_002231، XM_006718223

NM_001271430، NM_001271431، NM_001271432، NM_001271461، NM_001271462، NM_007656 NM_001136055، NM_001271430، NM_001271431، NM_001271432، NM_001271461، NM_001271462، NM_007656

RefSeq (پروتئین)

NP_002222، XP_006718286، XP_011518369 NP_001020015، NP_002222، XP_006718286، XP_011518369

NP_001258359، NP_001258360، NP_001258361، NP_001258390، NP_001258391، NP_031682 NP_001129527، NP_001258359، NP_001258360، NP_001258361، NP_001258390، NP_001258391، NP_031682

موقعیت (UCSC)ن/مChr : 93.25 – 93.29 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

مجموعه تمایزی ۸۲ (به انگلیسی: CD82) یک پروتئین است که در انسان توسط ژن «CD82» کُدگذاری می‌شود.[۴]

این ژن سرکوب‌کنندهٔ متاستاز، یک گلیکوپروتئین پوسته‌ای است که ساخت آن در تومورهای پیشرفت‌کننده کاهش یافته‌است و بیانِ آن با ژن پی۵۳ مرتبط است و توسط آن تحریک می‌شود.

پروتئین CD82 با مولکول‌های CD19،[۵][۶] CD63[۷] و CD234[۸] تعامل پروتئین-پروتئین دارد.

این پروتئین نقش مهمی در ایجاد آندومتریوز ایفا می‌کند.[۹]

جستارهای وابسته

[ویرایش]

منابع

[ویرایش]
  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027215 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Entrez Gene: CD82 CD82 molecule".
  5. ↑ Imai T, Kakizaki M, Nishimura M, Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology. 155 (3): 1229–39. PMID 7636191.
  6. ↑ Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.
  7. ↑ Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. PMID 9759843.
  8. ↑ Hur J, Choi JI, Lee H, Nham P, Kim TW, Chae CW, et al. (April 2016). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–21. doi:10.1016/j.stem.2016.01.013. PMID 26996598.
  9. ↑ Timologou, A; Zafrakas M; Grimbizis G; Miliaras D; Kotronis K; Stamatopoulos P; Tarlatzis B (February 2016). "Immunohistochemical expression pattern of metastasis suppressors". European Journal of Obstetrics & Gynecology and Reproductive Biology. 199: 110–115. doi:10.1016/j.ejogrb.2016.02.004. PMID 26918694.

برای مطالعهٔ بیشتر

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  • Imai T, Kakizaki M, Nishimura M, Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology. 155 (3): 1229–39. PMID 7636191.
  • Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC (May 1995). "KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2". Science. 268 (5212): 884–6. Bibcode:1995Sci...268..884D. doi:10.1126/science.7754374. PMID 7754374.
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  • Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (September 1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology. 157 (5): 2039–47. PMID 8757325.
  • Szöllósi J, Horejsí V, Bene L, Angelisová P, Damjanovich S (October 1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". Journal of Immunology. 157 (7): 2939–46. PMID 8816400.
  • Dong JT, Isaacs WB, Barrett JC, Isaacs JT (April 1997). "Genomic organization of the human KAI1 metastasis-suppressor gene". Genomics. 41 (1): 25–32. doi:10.1006/geno.1997.4618. PMID 9126478.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. PMID 9759843.
  • Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.
  • Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
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پیوند به بیرون

[ویرایش]
در ویکی‌انبار پرونده‌هایی دربارهٔ CD82 موجود است.
آیکون خرد

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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