PTPLAD1

HACD3
معین‌کننده‌ها
نام‌های دیگر	HACD3, B-IND1, BIND1, HSPC121, PTPLAD1, 3-hydroxyacyl-CoA dehydratase 3
شناسه‌های بیرونی	OMIM: 615940 MGI: 1889341 HomoloGene: 9494 GeneCards: HACD3
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	64,928,975 bp
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0005097، GO:0005099، GO:0005100 GTPase activator activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • lyase activity; • enzyme binding; • 3-hydroxyacyl-CoA dehydratase activity; • 3-hydroxy-lignoceroyl-CoA dehydratase activity; • 3-hydroxy-behenoyl-CoA dehydratase activity; • 3-hydroxy-arachidoyl-CoA dehydratase activity; • very-long-chain 3-hydroxyacyl-CoA dehydratase activity;
ترکیبات سلولی	• integral component of membrane; • پوشش هسته‌ای; • endoplasmic reticulum membrane; • membrane; • focal adhesion; • شبکه آندوپلاسمی; • میتوکندری; • سیتوزول; • integral component of endoplasmic reticulum membrane;
فرایند زیستی	• positive regulation by virus of viral protein levels in host cell; • سوخت‌وساز لیپید; • small GTPase mediated signal transduction; • Synthesis saturated fatty acids by metabolites; • JNK cascade; • fatty acid biosynthetic process; • very long-chain fatty acid biosynthetic process; • Rho protein signal transduction; • fatty acid elongation; • positive regulation of viral genome replication; • Rac protein signal transduction; • I-kappaB kinase/NF-kappaB signaling; • GO:0032320، GO:0032321، GO:0032855، GO:0043089، GO:0032854 positive regulation of GTPase activity; • sphingolipid biosynthetic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	51495
	57874
	ENSG00000074696
	ENSMUSG00000033629
	Q9P035
	Q8K2C9
	NM_016395 XM_011521664، NM_016395
	XR_001778950 NM_021345، XR_001778950
	XP_011519966 NP_057479، XP_011519966
	NP_067320
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین شبه تیروزین فسفاتاز پروتئین PTPLAD1 آنزیمی است که در انسان توسط ژن PTPLAD1 کدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000033629 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Courilleau D, Chastre E, Sabbah M, Redeuilh G, Atfi A, Mester J (Jul 2000). "B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts". J Biol Chem. 275 (23): 17344–8. doi:10.1074/jbc.M000887200. PMID 10747961.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
↑ "Entrez Gene: PTPLAD1 protein tyrosine phosphatase-like A domain containing 1".

جهت مطالعه

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Sabbah M, Saucier C, Redeuilh G (2006). "Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors". Gene. 374: 128–33. doi:10.1016/j.gene.2006.01.022. PMID 16516406.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000033629 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_10747961-4] Courilleau D, Chastre E, Sabbah M, Redeuilh G, Atfi A, Mester J (Jul 2000). "B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts". J Biol Chem. 275 (23): 17344–8. doi:10.1074/jbc.M000887200. PMID 10747961.

[pmid_11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[entrez-6] "Entrez Gene: PTPLAD1 protein tyrosine phosphatase-like A domain containing 1".

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