GABRG2

GABRG2
معین‌کننده‌ها
نام‌های دیگر	GABRG2, CAE2, ECA2, GEFSP3, gamma-aminobutyric acid type A receptor gamma2 subunit, EIEE74, FEB8
شناسه‌های بیرونی	OMIM: 137164 MGI: 95623 HomoloGene: 22443 GeneCards: GABRG2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	41,891,684 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • benzodiazepine receptor activity; • extracellular ligand-gated ion channel activity; • chloride channel activity; • GABA-A receptor activity; • ion channel activity; • transmembrane signaling receptor activity; • inhibitory extracellular ligand-gated ion channel activity; • GABA-gated chloride ion channel activity; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
ترکیبات سلولی	• integral component of membrane; • postsynaptic membrane; • membrane; • سیناپس; • dendrite membrane; • chloride channel complex; • آسه; • پیوند میان‌یاخته‌ای; • integral component of plasma membrane; • پوسته یاخته; • دندریت; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • cell projection; • GABA-A receptor complex; • neuron projection; • postsynapse; • GABA-ergic synapse;
فرایند زیستی	• gamma-aminobutyric acid signaling pathway; • synaptic transmission, GABAergic; • ion transport; • post-embryonic development; • adult behavior; • chloride transport; • cellular response to histamine; • chemical synaptic transmission; • chloride transmembrane transport; • ion transmembrane transport; • GO:0072468 ورارسانی پیام; • regulation of membrane potential; • nervous system process; • regulation of postsynaptic membrane potential; • inhibitory synapse assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2566
	14406
	ENSG00000113327
	ENSMUSG00000020436
	P18507
	P22723
	NM_000816، NM_198903 NM_198904، NM_000816، NM_198903
	NM_177408، NM_001362655، NM_001362656، XM_030245561، XM_036156333 NM_008073، NM_177408، NM_001362655، NM_001362656، XM_030245561، XM_036156333
	NP_944493، NP_944494، NP_001362268، NP_001362269، NP_001362270، NP_001362271، NP_001362272، NP_001362273، NP_001362274، NP_001362275، NP_001362276، NP_001362277، NP_001362278، NP_001362279 NP_000807، NP_944493، NP_944494، NP_001362268، NP_001362269، NP_001362270، NP_001362271، NP_001362272، NP_001362273، NP_001362274، NP_001362275، NP_001362276، NP_001362277، NP_001362278، NP_001362279
	NP_803127، NP_001349584، NP_001349585، XP_030101421، XP_036012226 NP_032099، NP_803127، NP_001349584، NP_001349585، XP_030101421، XP_036012226
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زیرواحد گاما-۲ گیرندهٔ گاما-آمینوبوتیریک اسید (انگلیسی: Gamma-aminobutyric acid receptor subunit gamma-2) یک پروتئین است که در انسان توسط ژن «GABRG2» کُدگذاری می‌شود.

این پروتئین با مولکول‌های GABARAP^[۴]^[۵]^[۶] و گیرنده دی۵ دوپامین^[۷] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

گیرنده گابا A

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020436 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.
↑ Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.
↑ Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.
↑ Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–280. Bibcode:2000Natur.403..274L. doi:10.1038/35002014. PMID 10659839. S2CID 4415918.

مشارکت‌کنندگان ویکی‌پدیا. «Gamma-aminobutyric acid receptor subunit gamma-2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020436 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11948245-4] Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.

[pmid11779480-5] Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.

[pmid9892355-6] Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.

[pmid10659839-7] Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–280. Bibcode:2000Natur.403..274L. doi:10.1038/35002014. PMID 10659839. S2CID 4415918.

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