CXCR4

CXCR4
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4RWS, 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 2N55
معین‌کننده‌ها
نام‌های دیگر	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C motif chemokine receptor 4, WHIMS1
شناسه‌های بیرونی	OMIM: 162643 MGI: 109563 HomoloGene: 20739 GeneCards: CXCR4
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	128,520,030 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0019974 cytokine binding; • coreceptor activity; • virus receptor activity; • signal transducer activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • chemokine receptor activity; • myosin light chain binding; • actin binding; • ubiquitin protein ligase binding; • G protein-coupled receptor activity; • C-X-C chemokine receptor activity; • ubiquitin binding; • C-C chemokine binding; • C-C chemokine receptor activity; • chemokine binding; • C-X-C motif chemokine 12 receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • اندوزوم; • membrane; • cell surface; • پیوند میان‌یاخته‌ای; • cell leading edge; • extracellular exosome; • GO:0016023 cytoplasmic vesicle; • early endosome; • late endosome; • کافنده‌تن; • پوسته یاخته; • external side of plasma membrane; • GO:0009327 protein-containing complex; • هسته یاخته;
فرایند زیستی	• myelin maintenance; • positive regulation of oligodendrocyte differentiation; • response to hypoxia; • positive regulation of cytosolic calcium ion concentration; • chemokine-mediated signaling pathway; • response to virus; • dendritic cell chemotaxis; • cellular response to cytokine stimulus; • کموتاکسی; • inflammatory response; • calcium-mediated signaling; • GO:0072468 ورارسانی پیام; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • GO:0022415 viral process; • fusion of virus membrane with host plasma membrane; • regulation of chemotaxis; • G protein-coupled receptor signaling pathway; • هدایت آسه; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • brain development; • عصب‌زایی; • CXCL12-activated CXCR4 signaling pathway; • cell chemotaxis; • positive regulation of cold-induced thermogenesis; • regulation of cell adhesion; • neuron migration; • epithelial cell development; • neuron recognition; • response to activity; • کوچ یاخته; • telencephalon cell migration; • positive regulation of cell migration; • positive regulation of vascular wound healing; • regulation of programmed cell death; • response to morphine; • endothelial cell differentiation; • positive regulation of neurogenesis; • regulation of viral process; • positive regulation of chemotaxis; • detection of temperature stimulus involved in sensory perception of pain; • detection of mechanical stimulus involved in sensory perception of pain; • regulation of calcium ion transport; • cardiac muscle contraction; • endothelial tube morphogenesis; • positive regulation of dendrite extension; • positive regulation of mesenchymal stem cell migration; • response to ultrasound;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7852
	12767
	ENSG00000121966
	ENSMUSG00000045382
	P61073
	P70658
	NM_001008540، NM_001348056، NM_001348059، NM_001348060، XM_047445802 NM_003467، NM_001008540، NM_001348056، NM_001348059، NM_001348060، XM_047445802
	XM_006529114، NM_001356509، XM_036157035 NM_009911، XM_006529114، NM_001356509، XM_036157035
	NP_003458، NP_001334985، NP_001334988، NP_001334989 NP_001008540، NP_003458، NP_001334985، NP_001334988، NP_001334989
	XP_006529177، NP_001343438، XP_036012928 NP_034041، XP_006529177، NP_001343438، XP_036012928
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

C-X-C chemokine receptor type 4 (انگلیسی: گیرندهٔ نوع ۴ کموکین سی-ایکس-سی) یا «CD184»، یک پروتئین است که انسان توسط ژن «CXCR4» کدگذاری می‌شود.^[۴]^[۵]

این پروتئین نوعی گیرندهٔ آلفا-کموکین اختصاصی برای مولکول پروتئینی SDF1 است که خاصیت کموتاکتیک قوی در جذب لنفوسیت‌ها دارد. SDF1 همچنین در لانه‌گزینی سلول‌های بنیادی خونساز در مغز استخوان نقش مهمی دارد. این پروتئین همچنین بیان ژنی CD20 را در لنفوسیت‌های بی تنظیم می‌کند.^[۶]

CXCR4 یکی از چند گیرندهٔ کموکین است که ویروس اچ‌آی‌وی جهت آلوده‌ساختنِ لنفوسیت‌های تی CD4+ از آنها استفاده می‌کند.

داروهای مسدودکنندهٔ این گیرنده قادرند سلول‌های بنیادی خونساز را به‌تحرک وادارند.

ثابت شده که مواجههٔ طولانی‌مدت با تتراهیدروکانابینول بیان CXCR4 را بر سطح لنفوسیت‌های تی CD4+ و CD8+ در میمون رزوس افزایش می‌دهد.^[۷]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000045382 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology. 159 (9): 4322–9. PMID 9379028.
↑ Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters. 426 (2): 271–8. doi:10.1016/S0014-5793(98)00359-7. PMID 9599023.
↑ Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M (August 2016). "Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis". Blood. 128: 1609–13. doi:10.1182/blood-2016-04-709519. PMID 27480113.
↑ LeCapitaine NJ, Zhang P, Winsauer P, Walker E, Vande Stouwe C, Porretta C, Molina PE (December 2011). "Chronic Δ-9-tetrahydrocannabinol administration increases lymphocyte CXCR4 expression in rhesus macaques". Journal of Neuroimmune Pharmacology. 6 (4): 540–5. doi:10.1007/s11481-011-9277-4. PMC 3181271. PMID 21484257.

مشارکت‌کنندگان ویکی‌پدیا. «CXCR4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۸ آوریل ۲۰۱۸.

برای مطالعهٔ بیشتر

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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000045382 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_9379028-4] Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology. 159 (9): 4322–9. PMID 9379028.

[pmid_9599023-5] Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters. 426 (2): 271–8. doi:10.1016/S0014-5793(98)00359-7. PMID 9599023.

[6] Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M (August 2016). "Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis". Blood. 128: 1609–13. doi:10.1182/blood-2016-04-709519. PMID 27480113.

[7] LeCapitaine NJ, Zhang P, Winsauer P, Walker E, Vande Stouwe C, Porretta C, Molina PE (December 2011). "Chronic Δ-9-tetrahydrocannabinol administration increases lymphocyte CXCR4 expression in rhesus macaques". Journal of Neuroimmune Pharmacology. 6 (4): 540–5. doi:10.1007/s11481-011-9277-4. PMC 3181271. PMID 21484257.

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