CD74

CD74
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1A6A, 1ICF, 1IIE, 1L3H, 1MUJ, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4X5W
معین‌کننده‌ها
نام‌های دیگر	CD74, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
شناسه‌های بیرونی	OMIM: 142790 MGI: 96534 HomoloGene: 3209 GeneCards: CD74
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۸ (موش)
پایان	60,945,724 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nitric-oxide synthase binding; • identical protein binding; • MHC class II protein binding, via antigen binding groove; • GO:0016518 cytokine receptor activity; • macrophage migration inhibitory factor binding; • protein folding chaperone activity; • MHC class II protein complex binding; • amyloid-beta binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • MHC class II protein binding; • GO:0019974 cytokine binding; • CD4 receptor binding;
ترکیبات سلولی	• lysosomal lumen; • extracellular exosome; • MHC class II protein complex; • lysosomal membrane; • late endosome; • endocytic vesicle membrane; • transport vesicle membrane; • integral component of membrane; • ER to Golgi transport vesicle membrane; • multivesicular body; • دستگاه گلژی; • Golgi membrane; • trans-Golgi network membrane; • macrophage migration inhibitory factor receptor complex; • membrane; • cell surface; • intracellular anatomical structure; • integral component of lumenal side of endoplasmic reticulum membrane; • شبکه آندوپلاسمی; • endoplasmic reticulum membrane; • پوسته یاخته; • کافنده‌تن; • کریچه; • اندوزوم; • clathrin-coated endocytic vesicle membrane; • NOS2-CD74 complex; • external side of plasma membrane;
فرایند زیستی	• GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • positive regulation of T cell differentiation; • negative regulation of apoptotic process; • GO:0072468 ورارسانی پیام; • positive thymic T cell selection; • chaperone cofactor-dependent protein refolding; • T cell selection; • positive regulation of type 2 immune response; • positive regulation of dendritic cell antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • adaptive immune response; • antigen processing and presentation; • positive regulation of peptidyl-tyrosine phosphorylation; • negative regulation of mature B cell apoptotic process; • regulation of macrophage activation; • negative regulation of DNA damage response, signal transduction by p53 class mediator; • immunoglobulin mediated immune response; • leukocyte migration; • positive regulation of neutrophil chemotaxis; • positive regulation of chemokine (C-X-C motif) ligand 2 production; • macrophage migration inhibitory factor signaling pathway; • prostaglandin biosynthetic process; • تکثیر سلولی; • antigen processing and presentation of endogenous antigen; • immune system process; • defense response; • negative regulation of peptide secretion; • negative regulation of T cell differentiation; • positive regulation of macrophage cytokine production; • positive regulation of B cell proliferation; • negative thymic T cell selection; • positive regulation of fibroblast proliferation; • intracellular protein transport; • positive regulation of ERK1 and ERK2 cascade; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • positive regulation of cytokine-mediated signaling pathway; • positive regulation of protein phosphorylation; • positive regulation of kinase activity; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of MAPK cascade; • positive regulation of monocyte differentiation; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of viral entry into host cell; • protein heterotetramerization; • protein trimerization; • GO:0034622 protein-containing complex assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	972
	16149
	ENSG00000019582
	ENSMUSG00000024610
	P04233
	P04441
	NM_001025158، NM_001025159، NM_001364083، NM_001364084، NR_157074 NM_004355، NM_001025158، NM_001025159، NM_001364083، NM_001364084، NR_157074
	NM_010545 NM_001042605، NM_010545
	NP_001020330، NP_004346، XP_016865578، XP_016865579، NP_001351012، NP_001351013 NP_001020329، NP_001020330، NP_004346، XP_016865578، XP_016865579، NP_001351012، NP_001351013
	NP_034675 NP_001036070، NP_034675
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زنجیرهٔ پادگن گامای مجموعه سازگاری بافتی اصلی کلاس دو (انگلیسی: HLA class II histocompatibility antigen gamma chain) که با نام CD74 هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «CD74» کُدگذاری می‌شود.^[۴]^[۵] این زنجیرهٔ ثابت و پایدار که به‌اختصار «Ii» گفته می‌شود، یک پپتید است که نقش مهمی در ارائه پادگن ایفا می‌کند و درتشکیل کمپلکس‌های شیمیایی مجموعه سازگاری بافتی اصلی کلاس دو دخالت دارد که در عملکرد لنفوسیت تی کمک‌کننده +CD4 حائز اهمیت است.^[۶]^[۷] در واقع شکل سطح سلولی زنجیرهٔ ثابت را CD74 می‌گویند که یک گیرندهٔ سطحی برای «فاکتور بازدارندهٔ حرکت ماکروفاژها» (MIF) محسوب می‌شود.^[۸]

اهمیت بالینی

از این زنجیرهٔ ثابت آنتی‌ژنی به‌عنوان ادجوان در تهیهٔ واکسن هپاتیت سی استفاده شده‌است که تأثیر واکسن را، به‌مراتب بیشتر نموده‌است.^[۹]

این مولکول پروتئینی در برخی از سلول‌های سرطانی هم یافت شده و شاید یکی از اهداف درمانی در اینگونه سرطان‌ها باشد.

اتوآنتی‌بادی علیه CD74 شاید یک نشانگر زیستی نویدبخش در تشخیص زودرس برخی بیماری‌های خودایمنی (همچون اسپوندیلیت آنکیلوزان) باشد.^[۱۰]

جستارهای وابسته

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024610 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Claesson L, Larhammar D, Rask L, Peterson PA (December 1983). "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure". Proceedings of the National Academy of Sciences of the United States of America. 80 (24): 7395–9. Bibcode:1983PNAS...80.7395C. doi:10.1073/pnas.80.24.7395. PMC 389957. PMID 6324166.
↑ Kudo J, Chao LY, Narni F, Saunders GF (December 1985). "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens". Nucleic Acids Research. 13 (24): 8827–41. doi:10.1093/nar/13.24.8827. PMC 318954. PMID 3001652.
↑ "UniProtKB - P04233 (HG2A_HUMAN)". The UniProt Knowledgebase. The UniProt Consortium. 2020. Retrieved Aug 10, 2020.
↑ Cresswell P (1994). "Assembly, transport, and function of MHC class II molecules". Annual Review of Immunology. 12: 259–93. doi:10.1146/annurev.iy.12.040194.001355. PMID 8011283.
↑ Farr L, Ghosh S, Moonah S (2020). "Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair". Frontiers in Immunology. 11: 1273. doi:10.3389/fimmu.2020.01273. PMC 7325688. PMID 32655566.
↑ Esposito I, Cicconi P, D'Alise AM, Brown A, Esposito M, Swadling L, et al. (June 2020). "MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans". Science Translational Medicine. 12 (548): eaaz7715. doi:10.1126/scitranslmed.aaz7715. PMID 32554708. S2CID 219722045. Archived from the original on 19 September 2020. Retrieved 4 September 2020.
↑ Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, et al. (June 2014). "Autoantibodies against CD74 in spondyloarthritis". Annals of the Rheumatic Diseases (به انگلیسی). 73 (6): 1211–4. doi:10.1136/annrheumdis-2012-202208. PMID 23687263. S2CID 22939188.

مشارکت‌کنندگان ویکی‌پدیا. «CD74». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۴ سپتامبر ۲۰۲۰.

برای مطالعهٔ بیشتر

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Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P (December 1992). "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides". Nature. 360 (6403): 474–7. Bibcode:1992Natur.360..474R. doi:10.1038/360474a0. PMID 1448172. S2CID 4338656.
Bakke O, Dobberstein B (November 1990). "MHC class II-associated invariant chain contains a sorting signal for endosomal compartments" (PDF). Cell. 63 (4): 707–16. doi:10.1016/0092-8674(90)90137-4. PMID 2121367. S2CID 19993336.
Marks MS, Blum JS, Cresswell P (September 1990). "Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens". The Journal of Cell Biology. 111 (3): 839–55. doi:10.1083/jcb.111.3.839. PMC 2116304. PMID 2391366.
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پیوند به بیرون

CD74 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CD74 انسانی و صفحهٔ جزئیات ژنی CD74 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024610 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_6324166-4] Claesson L, Larhammar D, Rask L, Peterson PA (December 1983). "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure". Proceedings of the National Academy of Sciences of the United States of America. 80 (24): 7395–9. Bibcode:1983PNAS...80.7395C. doi:10.1073/pnas.80.24.7395. PMC 389957. PMID 6324166.

[pmid_3001652-5] Kudo J, Chao LY, Narni F, Saunders GF (December 1985). "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens". Nucleic Acids Research. 13 (24): 8827–41. doi:10.1093/nar/13.24.8827. PMC 318954. PMID 3001652.

[UniProt-6] "UniProtKB - P04233 (HG2A_HUMAN)". The UniProt Knowledgebase. The UniProt Consortium. 2020. Retrieved Aug 10, 2020.

[pmid_8011283-7] Cresswell P (1994). "Assembly, transport, and function of MHC class II molecules". Annual Review of Immunology. 12: 259–93. doi:10.1146/annurev.iy.12.040194.001355. PMID 8011283.

[8] Farr L, Ghosh S, Moonah S (2020). "Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair". Frontiers in Immunology. 11: 1273. doi:10.3389/fimmu.2020.01273. PMC 7325688. PMID 32655566.

[Esposito2020-9] Esposito I, Cicconi P, D'Alise AM, Brown A, Esposito M, Swadling L, et al. (June 2020). "MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans". Science Translational Medicine. 12 (548): eaaz7715. doi:10.1126/scitranslmed.aaz7715. PMID 32554708. S2CID 219722045. Archived from the original on 19 September 2020. Retrieved 4 September 2020.

[10] Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, et al. (June 2014). "Autoantibodies against CD74 in spondyloarthritis". Annals of the Rheumatic Diseases (به انگلیسی). 73 (6): 1211–4. doi:10.1136/annrheumdis-2012-202208. PMID 23687263. S2CID 22939188.

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