گیرنده کلسی‌تونین

CALCR
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	5II0
معین‌کننده‌ها
نام‌های دیگر	CALCR, CRT, CT-R, CTR, CTR1, calcitonin receptor
شناسه‌های بیرونی	OMIM: 114131 MGI: 101950 HomoloGene: 1320 GeneCards: CALCR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	3,764,714 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • calcitonin receptor activity; • calcitonin binding; • signal transducer activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • transmembrane signaling receptor activity; • amyloid-beta binding; • calcitonin gene-related peptide receptor activity; • amylin receptor activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • پوسته یاخته; • integral component of plasma membrane; • آسه; • amylin receptor complex 1; • amylin receptor complex 2; • amylin receptor complex 3;
فرایند زیستی	• positive regulation of adenylate cyclase activity; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • receptor internalization; • response to glucocorticoid; • activation of phospholipase C activity; • activation of adenylate cyclase activity; • cell surface receptor signaling pathway; • protein transport; • protein localization to plasma membrane; • GO:0072468 ورارسانی پیام; • G protein-coupled receptor signaling pathway; • GO:1901313 positive regulation of gene expression; • positive regulation of protein kinase A signaling; • positive regulation of cell death; • positive regulation of peptidyl-serine phosphorylation; • cross-receptor inhibition within G protein-coupled receptor heterodimer; • positive regulation of protein kinase B signaling; • positive regulation of ERK1 and ERK2 cascade; • amylin receptor signaling pathway; • response to amyloid-beta; • positive regulation of calcium ion import across plasma membrane;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	799
	12311
	ENSG00000004948
	ENSMUSG00000023964
	P30988
	Q60755
	NM_001164737، NM_001164738 NM_001742، NM_001164737، NM_001164738
	NM_007588، NM_001355192، NM_001377018 NM_001042725، NM_007588، NM_001355192، NM_001377018
	NP_001158210، NP_001733 NP_001158209، NP_001158210، NP_001733
	NP_031614، NP_001342121، NP_001363947 NP_001036190، NP_031614، NP_001342121، NP_001363947
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده کلسی‌تونین (انگلیسی: Calcitonin receptor) یک گیرنده جفت‌شونده با پروتئین جی است که به هورمون کلسی‌تونین متصل می‌شود و در تنظیم هم‌ایستایی یون کلسیم^[۴] و به‌ویژه در ساخت استخوان و متابولیسم نقش دارد.^[۵]^[۶]^[۷]

این گیرنده با آپولیپوپروتئین B^[۸]^[۹] و LRP1^[۱۰] تعامل پروتئین-پروتئین دارد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000023964 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Receptors & Channels. 8 (3–4): 243–55. doi:10.1080/10606820213681. PMID 12529940.
↑ Chambers TJ, Magnus CJ (January 1982). "Calcitonin alters behaviour of isolated osteoclasts". The Journal of Pathology. 136 (1): 27–39. doi:10.1002/path.1711360104. PMID 7057295.
↑ Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (February 2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". The Journal of Cell Biology. 164 (4): 509–14. doi:10.1083/jcb.200312135. PMC 2171986. PMID 14970190.
↑ Davey RA, Turner AG, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, MacLean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (August 2008). "Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice". Journal of Bone and Mineral Research. 23 (8): 1182–93. doi:10.1359/jbmr.080310. PMC 2680171. PMID 18627265.
↑ Zhang J, Herscovitz H (February 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". The Journal of Biological Chemistry. 278 (9): 7459–68. doi:10.1074/jbc.M207976200. PMID 12397072.
↑ Linnik KM, Herscovitz H (August 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". The Journal of Biological Chemistry. 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. PMID 9694898.
↑ Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, Murphy-Ullrich JE (June 2003). "Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The Journal of Cell Biology. 161 (6): 1179–89. doi:10.1083/jcb.200302069. PMC 2172996. PMID 12821648.

مشارکت‌کنندگان ویکی‌پدیا. «Calcitonin receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر

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Pérez Jurado LA, Li X, Francke U (1995). "The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome". Cytogenetics and Cell Genetics. 70 (3–4): 246–9. doi:10.1159/000134044. PMID 7789182.
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Masi L, Becherini L, Gennari L, Colli E, Mansani R, Falchetti A, Cepollaro C, Gonnelli S, Tanini A, Brandi ML (April 1998). "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women". Biochemical and Biophysical Research Communications. 245 (2): 622–6. doi:10.1006/bbrc.1998.8445. PMID 9571205.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000023964 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12529940-4] Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Receptors & Channels. 8 (3–4): 243–55. doi:10.1080/10606820213681. PMID 12529940.

[pmid7057295-5] Chambers TJ, Magnus CJ (January 1982). "Calcitonin alters behaviour of isolated osteoclasts". The Journal of Pathology. 136 (1): 27–39. doi:10.1002/path.1711360104. PMID 7057295.

[pmid14970190-6] Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (February 2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". The Journal of Cell Biology. 164 (4): 509–14. doi:10.1083/jcb.200312135. PMC 2171986. PMID 14970190.

[pmid18627265-7] Davey RA, Turner AG, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, MacLean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (August 2008). "Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice". Journal of Bone and Mineral Research. 23 (8): 1182–93. doi:10.1359/jbmr.080310. PMC 2680171. PMID 18627265.

[pmid12397072-8] Zhang J, Herscovitz H (February 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". The Journal of Biological Chemistry. 278 (9): 7459–68. doi:10.1074/jbc.M207976200. PMID 12397072.

[pmid9694898-9] Linnik KM, Herscovitz H (August 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". The Journal of Biological Chemistry. 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. PMID 9694898.

[pmid12821648-10] Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, Murphy-Ullrich JE (June 2003). "Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The Journal of Cell Biology. 161 (6): 1179–89. doi:10.1083/jcb.200302069. PMC 2172996. PMID 12821648.

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