گیرنده مرگ ۳

TNFRSF25
معین‌کننده‌ها
نام‌های دیگر	TNFRSF25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, tumor necrosis factor receptor superfamily member 25, TNF receptor superfamily member 25, GEF720, PLEKHG5
شناسه‌های بیرونی	OMIM: 603366 MGI: 1934667 HomoloGene: 13202 GeneCards: TNFRSF25
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	152,204,576 bp
هستی‌شناسی ژن
عملکرد ملکولی	• tumor necrosis factor-activated receptor activity; • signaling receptor activity;
ترکیبات سلولی	• integral component of membrane; • extracellular region; • سیتوزول; • پوسته یاخته; • integral component of plasma membrane; • membrane;
فرایند زیستی	• regulation of apoptotic process; • multicellular organism development; • apoptotic signaling pathway; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • inflammatory response; • tumor necrosis factor-mediated signaling pathway; • regulation of cell population proliferation; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • GO:0072468 ورارسانی پیام; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8718
	85030
	ENSG00000215788
	ENSMUSG00000024793
	Q93038
	ن/م
	NM_001039664، NM_003790، NM_148965، NM_148966، NM_148967، NM_148968، NM_148969، NM_148970، NM_148971، NM_148972، NM_148973 NM_148974، NM_001039664، NM_003790، NM_148965، NM_148966، NM_148967، NM_148968، NM_148969، NM_148970، NM_148971، NM_148972، NM_148973
	NM_033042، XM_006539318، XM_006539319، XM_011250362، XM_030253942، XR_004942012 NM_001291010، NM_033042، XM_006539318، XM_006539319، XM_011250362، XM_030253942، XR_004942012
	NP_003781، NP_683866، NP_683867، NP_683868، NP_683871 NP_001034753، NP_003781، NP_683866، NP_683867، NP_683868، NP_683871
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده مرگ ۳ (انگلیسی: Death receptor 3) که با نام‌های DR3 و TNFRSF25 نیز شناخته می‌شود، یک گیرندهٔ سطح سلول از ابرخانواده گیرنده‌های فاکتور نکروز تومور است که در آپوپتوز و تمایز سلولی نقش دارد.^[۴]^[۵]^[۶]

اهمیت بالینی

آگونیست‌های این گیرنده موجب تحریک لنفوسیت‌های تی تنظیم‌کننده شده و با کاهش التهاب، می‌توانند در درمان آسم، التهاب قرنیه و افزایش موفقیت پیوند آلوژنیک نقش داشته باشند.^[۷]^[۸]^[۹]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024793 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J (Jan 1997). "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)". Immunity. 6 (1): 79–88. doi:10.1016/S1074-7613(00)80244-7. PMID 9052839.
↑ Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (Nov 1996). "A death-domain-containing receptor that mediates apoptosis". Nature. 384 (6607): 372–5. doi:10.1038/384372a0. PMID 8934525.
↑ "Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25".
↑ Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER (Oct 2010). "Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation". The Journal of Clinical Investigation. 120 (10): 3629–40. doi:10.1172/JCI42933. PMC 2947231. PMID 20890040.
↑ J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT (Oct 2012). "TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions". Journal of Virology. 86 (19): 10606–20. doi:10.1128/JVI.01391-12. PMC 3457251. PMID 22811539. Archived from the original on 3 February 2019. Retrieved 3 February 2019.
↑ Wolf D, Schreiber TH, Tryphonopoulos P, Li S, Tzakis AG, Ruiz P, Podack ER (Sep 2012). "Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival". Transplantation. 94 (6): 569–74. doi:10.1097/TP.0b013e318264d3ef. PMID 22902792.

مشارکت‌کنندگان ویکی‌پدیا. «Death receptor 3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۱۹.

برای مطالعهٔ بیشتر

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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024793 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9052839-4] Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J (Jan 1997). "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)". Immunity. 6 (1): 79–88. doi:10.1016/S1074-7613(00)80244-7. PMID 9052839.

[pmid8934525-5] Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (Nov 1996). "A death-domain-containing receptor that mediates apoptosis". Nature. 384 (6607): 372–5. doi:10.1038/384372a0. PMID 8934525.

[entrez-6] "Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25".

[Schreiber,_Taylor_H.;_Wolf,_Dietlinde;_Tsai,_Matthew;_et_al._2010_3629–40-7] Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER (Oct 2010). "Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation". The Journal of Clinical Investigation. 120 (10): 3629–40. doi:10.1172/JCI42933. PMC 2947231. PMID 20890040.

[8] J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT (Oct 2012). "TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions". Journal of Virology. 86 (19): 10606–20. doi:10.1128/JVI.01391-12. PMC 3457251. PMID 22811539. Archived from the original on 3 February 2019. Retrieved 3 February 2019.

[9] Wolf D, Schreiber TH, Tryphonopoulos P, Li S, Tzakis AG, Ruiz P, Podack ER (Sep 2012). "Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival". Transplantation. 94 (6): 569–74. doi:10.1097/TP.0b013e318264d3ef. PMID 22902792.

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