پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز

ADCYAP1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1GEA, 2D2P, 2JOD
معین‌کننده‌ها
نام‌های دیگر	ADCYAP1, PACAP, adenylate cyclase activating polypeptide 1
شناسه‌های بیرونی	OMIM: 102980 MGI: 105094 HomoloGene: 869 GeneCards: ADCYAP1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۷ (موش)
پایان	93,513,965 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• pituitary adenylate cyclase activating polypeptide activity; • hormone activity; • peptide hormone receptor binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • pituitary adenylate cyclase-activating polypeptide receptor binding; • neuropeptide hormone activity; • signaling receptor binding;
ترکیبات سلولی	• intracellular anatomical structure; • extracellular region; • پایانه آکسون; • extracellular space; • neuron projection; • پریکاریون; • cell body fiber;
فرایند زیستی	• histamine secretion; • pituitary gland development; • regulation of G protein-coupled receptor signaling pathway; • negative regulation of glial cell proliferation; • female pregnancy; • cell-cell signaling; • negative regulation of cell cycle; • negative regulation of muscle cell apoptotic process; • behavioral fear response; • جنین‌شناسی دستگاه عصبی مرکزی; • activation of adenylate cyclase activity; • regulation of protein localization; • GO:0032320، GO:0032321، GO:0032855، GO:0043089، GO:0032854 positive regulation of GTPase activity; • ATP metabolic process; • negative regulation of acute inflammatory response to non-antigenic stimulus; • regulation of oligodendrocyte progenitor proliferation; • cellular response to glucocorticoid stimulus; • GO:1901313 positive regulation of gene expression; • GO:0034259 negative regulation of GTPase activity; • positive regulation of synaptic transmission, glutamatergic; • positive regulation of chemokine (C-C motif) ligand 5 production; • regulation of postsynaptic membrane potential; • positive regulation of cell population proliferation; • negative regulation of potassium ion transport; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of interleukin-6 production; • positive regulation of neuron projection development; • پاسخ به گرسنگی; • ovarian follicle development; • درد نوسیسپتیو; • response to ethanol; • negative regulation of acute inflammatory response to antigenic stimulus; • neuropeptide signaling pathway; • neuron projection development; • cAMP-mediated signaling; • positive regulation of somatostatin secretion; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein kinase activity; • regulation of protein phosphorylation; • positive regulation of cytosolic calcium ion concentration; • insulin secretion; • positive regulation of growth hormone secretion; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of cAMP-mediated signaling; • brain development; • camera-type eye development; • positive regulation of cold-induced thermogenesis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	116
	11516
	ENSG00000141433
	ENSMUSG00000024256
	P18509
	O70176
	NM_001099733، NM_001117، XM_047437288 XM_005258081، NM_001099733، NM_001117، XM_047437288
	XM_006523498، XM_006523499، NM_001315503، NM_001315504، XM_017317212، XM_030249450، XM_036160267 NM_009625، XM_006523498، XM_006523499، NM_001315503، NM_001315504، XM_017317212، XM_030249450، XM_036160267
	NP_001108، XP_005258138 NP_001093203، NP_001108، XP_005258138
	NP_001302433، NP_033755، XP_006523561، XP_006523562، XP_017172701 NP_001302432، NP_001302433، NP_033755، XP_006523561، XP_006523562، XP_017172701
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پُلی‌پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز (انگلیسی: Pituitary adenylate cyclase-activating polypeptide) یا به‌اختصار PACAP یک پروتئین است که در انسان توسط ژن «ADCYAP1» کدگذاری می‌شود.^[۴]^[۵]

این پروتئین شباهت‌هایی به پپتید وازواکتیو روده‌ای (VIP) دارد و یکی از کارهایش، تحریک سلول‌های شبه‌انتروکرومافین در معده است. این پروتئین به گیرنده پپتید وازواکتیو روده‌ای و گیرندهٔ پُلی‌پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز اتصال می‌یابد.

اخیراً گونه‌ای از این پروتئین با بروز اختلال استرسی پس از آسیب روانی در زنان (و نه مردان) مرتبط دانسته‌اند.^[۶]

پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز با گیرنده سکرتین، تعامل پروتئین-پروتئین دارد.^[۷]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024256 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hosoya M, Kimura C, Ogi K, Ohkubo S, Miyamoto Y, Kugoh H, Shimizu M, Onda H, Oshimura M, Arimura A, et al. (Feb 1992). "Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene". Biochim Biophys Acta. 1129 (2): 199–206. doi:10.1016/0167-4781(92)90488-l. PMID 1730060.
↑ "Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)".
↑ Ressler, KJ; Mercer, KB; Bradley, B; Jovanovic, T; Mahan, A; Kerley, K; Norrholm, SD; Kilaru, V; Smith, AK; Myers, AJ; Ramirez, M; Engel, A; Hammack, SE; Toufexis, D; Braas, KM; Binder, EB; May, V (Feb 24, 2011). "Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor". Nature. 470 (7335): 492–7. Bibcode:2011Natur.470..492R. doi:10.1038/nature09856. PMC 3046811. PMID 21350482.
↑ Felley, C P; Qian J M; Mantey S; Pradhan T; Jensen R T (Dec 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. UNITED STATES. 263 (6 Pt 1): G901–7. ISSN 0002-9513. PMID 1335692. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)

مشارکت‌کنندگان ویکی‌پدیا. «Pituitary adenylate cyclase-activating peptide». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۸.

بیشتر بخوانید

Conconi MT, Spinazzi R, Nussdorfer GG (2006). "Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland". Int. Rev. Cytol. 249: 1–51. doi:10.1016/S0074-7696(06)49001-X. PMID 16697281.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (2000). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". J. Neuroendocrinol. 11 (12): 941–9. doi:10.1046/j.1365-2826.1999.00411.x. PMID 10583729.
Fahrenkrug J (2002). "Gut/brain peptides in the genital tract: VIP and PACAP". Scand. J. Clin. Lab. Invest. Suppl. 234: 35–9. PMID 11713978.
Fahrenkrug J (2006). "PACAP--a multifacetted neuropeptide". Chronobiol. Int. 23 (1–2): 53–61. doi:10.1080/07420520500464569. PMID 16687279.
Felley CP, Qian JM, Mantey S, et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692.
Geng L, Ju G (2000). "[The discovery of pituitary adenylate cyclase activating polypeptide (PACAP) and its research progress]". Sheng li ke xue jin zhan [Progress in physiology]. 28 (1): 29–34. PMID 10921074.
Gourlet P, Vandermeers A, Robberecht P, Deschodt-Lanckman M (1997). "Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP-27, but not PACAP-38) degradation by the neutral endopeptidase EC 3.4.24.11". Biochem. Pharmacol. 54 (4): 509–15. doi:10.1016/S0006-2952(97)00207-4. PMID 9313778.
Inagaki N, Yoshida H, Mizuta M, et al. (1994). "Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2679–83. Bibcode:1994PNAS...91.2679I. doi:10.1073/pnas.91.7.2679. PMC 43433. PMID 8146174.
Inooka H, Endo S, Kitada C, et al. (1993). "Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution". Int. J. Pept. Protein Res. 40 (5): 456–64. doi:10.1111/j.1399-3011.1992.tb00324.x. PMID 1483839.
Kimura C, Ohkubo S, Ogi K, et al. (1990). "A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs". Biochem. Biophys. Res. Commun. 166 (1): 81–9. doi:10.1016/0006-291X(90)91914-E. PMID 2302217.
Nakata M, Yada T (2007). "PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential". Curr. Pharm. Des. 13 (11): 1105–12. doi:10.2174/138161207780618948. PMID 17430174.
Ohkubo S, Kimura C, Ogi K, et al. (1992). "Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide". DNA Cell Biol. 11 (1): 21–30. doi:10.1089/dna.1992.11.21. PMID 1739432.
Ohtaki T, Masuda Y, Ishibashi Y, et al. (1994). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". J. Biol. Chem. 268 (35): 26650–7. PMID 8253796.
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Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, Fournier A, Chow BK, Hashimoto H, Galas L, Vaudry H (2009). "Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery". Pharmacol. Rev. 61 (3): 283–357. doi:10.1124/pr.109.001370. PMID 19805477.{{cite journal}}: نگهداری یادکرد:نام‌های متعدد:فهرست نویسندگان (link)
Waschek JA (2002). "Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration". Dev. Neurosci. 24 (1): 14–23. doi:10.1159/000064942. PMID 12145407.
Weber B, Riess O, Daneshvar H, et al. (1993). "(CA)n-dinucleotide repeat at the PDEB locus in 4p16.3". Hum. Mol. Genet. 2 (6): 827. doi:10.1093/hmg/2.6.827. PMID 8394765.
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Zeng N, Athmann C, Kang T, et al. (1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". J. Clin. Invest. 104 (10): 1383–91. doi:10.1172/JCI7537. PMC 409843. PMID 10562300.

پیوند به بیرون

Pituitary adenylate cyclase-activating polypeptide در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024256 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1730060-4] Hosoya M, Kimura C, Ogi K, Ohkubo S, Miyamoto Y, Kugoh H, Shimizu M, Onda H, Oshimura M, Arimura A, et al. (Feb 1992). "Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene". Biochim Biophys Acta. 1129 (2): 199–206. doi:10.1016/0167-4781(92)90488-l. PMID 1730060.

[entrez-5] "Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)".

[Ressler_2011-6] Ressler, KJ; Mercer, KB; Bradley, B; Jovanovic, T; Mahan, A; Kerley, K; Norrholm, SD; Kilaru, V; Smith, AK; Myers, AJ; Ramirez, M; Engel, A; Hammack, SE; Toufexis, D; Braas, KM; Binder, EB; May, V (Feb 24, 2011). "Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor". Nature. 470 (7335): 492–7. Bibcode:2011Natur.470..492R. doi:10.1038/nature09856. PMC 3046811. PMID 21350482.

[pmid1335692-7] Felley, C P; Qian J M; Mantey S; Pradhan T; Jensen R T (Dec 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. UNITED STATES. 263 (6 Pt 1): G901–7. ISSN 0002-9513. PMID 1335692. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)

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