بکلین ۱

BECN1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: K7ER46 PDBe K7ER46 RCSB
فهرست شناسه‌های PDB
	2P1L, 2PON, 3DVU, 4DDP, 4MI8
معین‌کننده‌ها
نام‌های دیگر	BECN1, ATG6, VPS30, beclin1, beclin 1
شناسه‌های بیرونی	OMIM: 604378 MGI: 1891828 HomoloGene: 2794 GeneCards: BECN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	101,193,112 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• phosphatidylinositol 3-kinase binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GTPase binding; • ubiquitin protein ligase binding; • protein kinase binding; • protein homodimerization activity;
ترکیبات سلولی	• endosome membrane; • سیتوپلاسم; • mitochondrial membranes; • trans-Golgi network; • دستگاه گلژی; • سیتوزول; • هسته یاخته; • autophagosome; • phagophore assembly site; • membrane; • دندریت; • شبکه آندوپلاسمی; • phosphatidylinositol 3-kinase complex, class III; • endoplasmic reticulum membrane; • phosphatidylinositol 3-kinase complex, class III, type II; • GO:0016023 cytoplasmic vesicle; • اندوزوم; • extrinsic component of membrane; • phosphatidylinositol 3-kinase complex, class III, type I; • phagocytic vesicle; • میتوکندری; • GO:0009327 protein-containing complex;
فرایند زیستی	• negative regulation of cell population proliferation; • response to hypoxia; • cellular response to aluminum ion; • response to vitamin E; • lysosome organization; • چرخه یاخته‌ای; • positive regulation of phosphatidylinositol 3-kinase signaling; • cellular response to glucose starvation; • cellular defense response; • تقسیم درون‌یاخته; • cellular response to epidermal growth factor stimulus; • تقسیم یاخته; • receptor catabolic process; • autophagy of nucleus; • cellular response to nitrogen starvation; • GO:0022415 viral process; • late endosome to vacuole transport; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • cytoplasm to vacuole transport by the Cvt pathway; • اندوسیتوز; • engulfment of apoptotic cell; • positive regulation of attachment of mitotic spindle microtubules to kinetochore; • amyloid-beta metabolic process; • neuron development; • defense response to virus; • response to other organism; • mitotic metaphase plate congression; • GO:0048552 regulation of catalytic activity; • negative regulation of reactive oxygen species metabolic process; • regulation of cytokinesis; • negative regulation of apoptotic process; • negative regulation of cell death; • autophagosome assembly; • macroautophagy; • GO:0010260 پیرش; • response to iron(II) ion; • response to lead ion; • protein deubiquitination; • response to nutrient levels; • cellular response to amino acid starvation; • cellular response to hydrogen peroxide; • cellular response to copper ion; • negative regulation of lysosome organization; • positive regulation of autophagosome assembly; • میتوفاژی; • mitophagy; • خودخواری; • positive regulation of autophagy; • response to mitochondrial depolarisation; • early endosome to late endosome transport; • negative regulation of autophagy; • positive regulation of cardiac muscle hypertrophy; • negative regulation of autophagosome assembly; • positive regulation of intrinsic apoptotic signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8678
	56208
	ENSG00000126581
	ENSMUSG00000035086
	K7ER46 Q14457، K7ER46
	O88597
	NM_001313999، NM_001314000، NM_003766، XM_005257759، XM_005257760، XM_017025263، XM_017025264 NM_001313998، NM_001313999، NM_001314000، NM_003766، XM_005257759، XM_005257760، XM_017025263، XM_017025264
	NM_001359819، NM_001359820، NM_001359821 NM_019584، NM_001359819، NM_001359820، NM_001359821
	NP_001300928، NP_001300929، NP_003757، XP_005257816، XP_005257817، XP_011523723، XP_016880751، XP_016880752، XP_016880753 NP_001300927، NP_001300928، NP_001300929، NP_003757، XP_005257816، XP_005257817، XP_011523723، XP_016880751، XP_016880752، XP_016880753
	NP_001346748، NP_001346749، NP_001346750 NP_062530، NP_001346748، NP_001346749، NP_001346750
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

بکلین ۱ (انگلیسی: Beclin-1) یک پروتئین است که در انسان توسط ژن «BECN1» کُدگذاری می‌شود.^[۴]^[۵] این پروتئین با Bcl-2 و «PI-3K نوع ۳» تعامل پروتئین-پروتئین دارد و نقش بسیار مهمی در تنظیم خودخواری و مرگ یاخته ایفا می‌کند.

اهمیت بالینی

بکلین ۱ از طریق دخالت در خودخواری و مرگ یاخته، نقش مهمی در سرطان‌زایی و زوال عصبی انسان بازی می‌کند.^[۶] در سرطان‌های تخمدانی که این میزان خودخواری بالاست، ماهیت تهاجمی کمتری دارد و پاسخ بهتری به شیمی‌درمانی می‌دهند.^[۷]

بروز اسکیزوفرنی با سطح کم بکلین ۱ در هیپوکامپ مرتبط است که سبب کاهش خودخواری و افزایش مرگ سلول‌های عصبی می‌گردد.^[۸]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035086 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.
↑ "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)".
↑ Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. (April 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389. PMID 19270693.
↑ Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
↑ Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. (February 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMC 4320293. PMID 24365867.*Lay summary in: Whiteman H (January 1, 2014). "New molecular discovery provides clues to cause of schizophrenia". MediLexicon International Ltd.

مشارکت‌کنندگان ویکی‌پدیا. «BECN1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

Funderburk SF, Wang QJ, Yue Z (June 2010). "The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond". Trends in Cell Biology. 20 (6): 355–62. doi:10.1016/j.tcb.2010.03.002. PMC 3781210. PMID 20356743.
Rommens JM, Durocher F, McArthur J, Tonin P, LeBlanc JF, Allen T, et al. (August 1995). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, et al. (July 1999). "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21". Genomics. 59 (1): 59–65. doi:10.1006/geno.1999.5851. PMID 10395800.
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B (December 1999). "Induction of autophagy and inhibition of tumorigenesis by beclin 1". Nature. 402 (6762): 672–6. Bibcode:1999Natur.402..672L. doi:10.1038/45257. PMID 10604474. S2CID 4423132.
Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T (April 2001). "Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network". EMBO Reports. 2 (4): 330–5. doi:10.1093/embo-reports/kve061. PMC 1083858. PMID 11306555.
Liang XH, Yu J, Brown K, Levine B (April 2001). "Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function". Cancer Research. 61 (8): 3443–9. PMID 11309306.
Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ (October 2001). "Use of chromatin immunoprecipitation to clone novel E2F target promoters". Molecular and Cellular Biology. 21 (20): 6820–32. doi:10.1128/MCB.21.20.6820-6832.2001. PMC 99859. PMID 11564866.
Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (August 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933.
Song H, Xia SL, Liao C, Li YL, Wang YF, Li TP, Zhao MJ (February 2004). "Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma". World Journal of Gastroenterology. 10 (4): 509–13. doi:10.3748/wjg.v10.i4.509. PMC 4716970. PMID 14966907.
Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, et al. (April 2004). "Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1". The Journal of Biological Chemistry. 279 (18): 18384–91. doi:10.1074/jbc.M313561200. PMID 14970205.
Furuya D, Tsuji N, Yagihashi A, Watanabe N (July 2005). "Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity". Experimental Cell Research. 307 (1): 26–40. doi:10.1016/j.yexcr.2005.02.023. PMID 15922724.
Kruse KB, Brodsky JL, McCracken AA (January 2006). "Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ". Molecular Biology of the Cell. 17 (1): 203–12. doi:10.1091/mbc.E04-09-0779. PMC 1345659. PMID 16267277.
Zeng X, Overmeyer JH, Maltese WA (January 2006). "Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking". Journal of Cell Science. 119 (Pt 2): 259–70. doi:10.1242/jcs.02735. PMID 16390869.
Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, et al. (May 2006). "Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1". The Journal of Biological Chemistry. 281 (20): 14474–85. doi:10.1074/jbc.M600364200. PMID 16522639.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Daniel F, Legrand A, Pessayre D, Vadrot N, Descatoire V, Bernuau D (May 2006). "Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells". World Journal of Gastroenterology. 12 (18): 2895–900. doi:10.3748/wjg.v12.i18.2895. PMC 4087807. PMID 16718815.

پیوند به بیرون

مکان ژنوم BECN1 انسانی و صفحهٔ جزئیات ژنی BECN1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q14457 (Beclin-1) در PDBe-KB.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035086 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9765397-4] Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.

[entrez-5] "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)".

[pmid19270693-6] Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. (April 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389. PMID 19270693.

[Valente_2014-7] Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.

[pmid24365867-8] Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. (February 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMC 4320293. PMID 24365867.*Lay summary in: Whiteman H (January 1, 2014). "New molecular discovery provides clues to cause of schizophrenia". MediLexicon International Ltd.

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