HTRA2

HTRA2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1LCY, 2PZD
معین‌کننده‌ها
نام‌های دیگر	HTRA2, Htra2, AI481710, Omi, Prss25, mnd2, PARK13, HtrA serine peptidase 2, MGCA8
شناسه‌های بیرونی	OMIM: 606441 MGI: 1928676 HomoloGene: 113300 GeneCards: HTRA2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	83,032,254 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• unfolded protein binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • serine-type peptidase activity; • serine-type endopeptidase activity; • hydrolase activity; • GO:0070122 peptidase activity; • identical protein binding;
ترکیبات سلولی	• integral component of membrane; • سیتوزول; • endoplasmic reticulum membrane; • membrane; • mitochondrial membranes; • mitochondrial intermembrane space; • شبکه آندوپلاسمی; • میتوکندری; • CD40 receptor complex; • cytoplasmic side of plasma membrane; • کروماتین; • اسکلت سلولی; • هسته یاخته; • serine-type endopeptidase complex;
فرایند زیستی	• cellular response to retinoic acid; • cellular response to heat; • positive regulation of cell death; • ceramide metabolic process; • cellular response to interferon-beta; • regulation of multicellular organism growth; • positive regulation of protein targeting to mitochondrion; • execution phase of apoptosis; • adult locomotory behavior; • cellular response to growth factor stimulus; • pentacyclic triterpenoid metabolic process; • mitochondrion organization; • negative regulation of cell cycle; • neuron development; • protein autoprocessing; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • negative regulation of cell death; • intrinsic apoptotic signaling pathway; • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; • regulation of autophagy of mitochondrion; • intrinsic apoptotic signaling pathway in response to DNA damage; • positive regulation of apoptotic process; • forebrain development; • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • response to herbicide; • adult walking behavior; • negative regulation of neuron death; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • GO:0010260 پیرش; • پروتئین‌کافت; • positive regulation of mitochondrion organization; • cellular response to oxidative stress; • negative regulation of mitophagy in response to mitochondrial depolarization; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • protein homotrimerization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	27429
	64704
	ENSG00000115317
	ENSMUSG00000068329
	O43464
	Q9JIY5
	NM_145074، NM_001321727، NM_001321728، NR_135769، NR_135770، NR_135771، NR_135772 NM_013247، NM_145074، NM_001321727، NM_001321728، NR_135769، NR_135770، NR_135771، NR_135772
	NM_019752
	NP_001308657، NP_037379، NP_659540 NP_001308656، NP_001308657، NP_037379، NP_659540
	NP_062726
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

HTRA2 (انگلیسی: HtrA serine peptidase 2) با نامِ کاملِ «سرین پپتیداز HTRA2 میتوکندریایی» یک آنزیم است که در انسان توسط ژن «HTRA2» کُد می‌شود.^[۴]^[۵]^[۶]

ژن کدکنندهٔ این آنزیم، ۸ اگزون دارد و بر روی کروموزوم ۱۲ واقع است.

این آنزیم در فرایند «آپوپتوز وابسته به کاسپاز» و همچنین بیماری پارکینسون دخیل است^[۷]^[۸] و در پاتوژنز سرطان^[۹] و برخی بیماری‌هایی نورودژنراتیو نقش دارد.^[۱۰]

شواهد قابل‌اعتماد و محکمی برای نقش این ژن در ایجاد سرطان به دست آمده‌است. این آنزیمِ پروتئینی در تعداد گوناگونی از سلول‌های سرطانی تولید می‌شود.^[۱۱]^[۱۲]^[۱۳]^[۱۴]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000068329 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Faccio L, Fusco C, Chen A, Martinotti S, Bonventre JV, Zervos AS (Jan 2000). "Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia". The Journal of Biological Chemistry. 275 (4): 2581–8. doi:10.1074/jbc.275.4.2581. PMID 10644717.
↑ Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL (Sep 2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". European Journal of Biochemistry / FEBS. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
↑ "Entrez Gene: HTRA2 HtrA serine peptidase 2".
↑ Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES (Oct 2003). "Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice". Nature. 425 (6959): 721–7. doi:10.1038/nature02052. PMID 14534547.
↑ Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R (Aug 2005). "Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease". Human Molecular Genetics. 14 (15): 2099–111. doi:10.1093/hmg/ddi215. PMID 15961413.
↑ Bulteau AL, Bayot A (Jun 2011). "Mitochondrial proteases and cancer". Biochimica et Biophysica Acta. 1807 (6): 595–601. doi:10.1016/j.bbabio.2010.12.011. PMID 21194520.
↑ Vande Walle L, Lamkanfi M, Vandenabeele P (Mar 2008). "The mitochondrial serine protease HtrA2/Omi: an overview". Cell Death and Differentiation. 15 (3): 453–60. doi:10.1038/sj.cdd.4402291. PMID 18174901.
↑ Bowden MA, Di Nezza-Cossens LA, Jobling T, Salamonsen LA, Nie G (Oct 2006). "Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer". Gynecologic Oncology. 103 (1): 253–60. doi:10.1016/j.ygyno.2006.03.006. PMID 16650464.
↑ Lee SH, Lee JW, Kim HS, Kim SY, Park WS, Kim SH, Lee JY, Yoo NJ (May 2003). "Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer". APMIS. 111 (5): 586–90. doi:10.1034/j.1600-0463.2003.1110508.x. PMID 12887511.
↑ Narkiewicz J, Klasa-Mazurkiewicz D, Zurawa-Janicka D, Skorko-Glonek J, Emerich J, Lipinska B (May 2008). "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer". Clinical Biochemistry. 41 (7–8): 561–9. doi:10.1016/j.clinbiochem.2008.01.004. PMID 18241672.
↑ Zurawa-Janicka D, Kobiela J, Stefaniak T, Wozniak A, Narkiewicz J, Wozniak M, Limon J, Lipinska B (2008). "Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster". Acta Biochimica Polonica. 55 (1): 9–19. PMID 18231652.

مشارکت‌کنندگان ویکی‌پدیا. «HtrA serine peptidase 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۱ اکتبر ۲۰۱۷.

این یک مقالهٔ خرد آنزیم ، پروتئین یا زیست‌مولکول است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000068329 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_10644717-4] Faccio L, Fusco C, Chen A, Martinotti S, Bonventre JV, Zervos AS (Jan 2000). "Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia". The Journal of Biological Chemistry. 275 (4): 2581–8. doi:10.1074/jbc.275.4.2581. PMID 10644717.

[pmid_10971580-5] Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL (Sep 2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". European Journal of Biochemistry / FEBS. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.

[entrez-6] "Entrez Gene: HTRA2 HtrA serine peptidase 2".

[pmid14534547-7] Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES (Oct 2003). "Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice". Nature. 425 (6959): 721–7. doi:10.1038/nature02052. PMID 14534547.

[pmid15961413-8] Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R (Aug 2005). "Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease". Human Molecular Genetics. 14 (15): 2099–111. doi:10.1093/hmg/ddi215. PMID 15961413.

[9] Bulteau AL, Bayot A (Jun 2011). "Mitochondrial proteases and cancer". Biochimica et Biophysica Acta. 1807 (6): 595–601. doi:10.1016/j.bbabio.2010.12.011. PMID 21194520.

[ReferenceA-10] Vande Walle L, Lamkanfi M, Vandenabeele P (Mar 2008). "The mitochondrial serine protease HtrA2/Omi: an overview". Cell Death and Differentiation. 15 (3): 453–60. doi:10.1038/sj.cdd.4402291. PMID 18174901.

[11] Bowden MA, Di Nezza-Cossens LA, Jobling T, Salamonsen LA, Nie G (Oct 2006). "Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer". Gynecologic Oncology. 103 (1): 253–60. doi:10.1016/j.ygyno.2006.03.006. PMID 16650464.

[12] Lee SH, Lee JW, Kim HS, Kim SY, Park WS, Kim SH, Lee JY, Yoo NJ (May 2003). "Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer". APMIS. 111 (5): 586–90. doi:10.1034/j.1600-0463.2003.1110508.x. PMID 12887511.

[13] Narkiewicz J, Klasa-Mazurkiewicz D, Zurawa-Janicka D, Skorko-Glonek J, Emerich J, Lipinska B (May 2008). "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer". Clinical Biochemistry. 41 (7–8): 561–9. doi:10.1016/j.clinbiochem.2008.01.004. PMID 18241672.

[14] Zurawa-Janicka D, Kobiela J, Stefaniak T, Wozniak A, Narkiewicz J, Wozniak M, Limon J, Lipinska B (2008). "Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster". Acta Biochimica Polonica. 55 (1): 9–19. PMID 18231652.

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]

[۷]

[۸]

[۹]

[۱۰]

[۱۱]

[۱۲]

[۱۳]

[۱۴]